If a resource appears after a comment sequence in a string (such as a URL), ResX Manager does not recognizes this as a valid resource usage:
string url = string.Format("{0}://{1}?{2}", secure ? "https" : "http", domain, Resources.File.Key);
string url = string.Format("{0}://{1}?{2}", secure ? "https" : "http", domain, Resources.File.Key);